EYA3 抗体 (AA 1-300)
Quick Overview for EYA3 抗体 (AA 1-300) (ABIN7152363)
抗原
See all EYA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-300
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Eyes absent homolog 3 protein (1-300AA)
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亚型
- IgG
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anti-Eyes Absent Homolog 3 (EYA3) antibody
EYA3 适用: 人, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (AA 277-326) antibodyEYA3 适用: 人, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (AA 1-300) antibodyEYA3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Eyes Absent Homolog 3 (EYA3) (Middle Region) antibodyEYA3 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, Cow, 马, 绵羊, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- EYA3 (Eyes Absent Homolog 3 (EYA3))
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别名
- EYA3
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背景
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Background: Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Aliases: AI844637 antibody, DKFZp686C132 antibody, EYA3 antibody, EYA3_HUMAN antibody, Eyes absent 3 antibody, Eyes absent 3 homolog (Drosophila) antibody, Eyes absent homolog 3 antibody, OTTMUSP00000010370 antibody, RP11-460I13.4 antibody, RP23-442A20.1 antibody
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UniProt
- Q99504
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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