EIF2AK1 抗体 (AA 1-86)
Quick Overview for EIF2AK1 抗体 (AA 1-86) (ABIN7152137)
抗原
See all EIF2AK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-86
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交叉反应
- 人, 大鼠
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 1 protein (1-86AA)
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亚型
- IgG
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anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibody
EIF2AK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (N-Term) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 108-157) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (N-Term) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibodyEIF2AK1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-630) antibodyEIF2AK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (C-Term) antibodyEIF2AK1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 371-630) antibodyEIF2AK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (C-Term) antibodyEIF2AK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
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别名
- EIF2AK1
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背景
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Background: Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at \\\'Ser-48\\\' and \\\'Ser-51\\\', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).
Aliases: E2AK1_HUMAN antibody, EC 2.7.11.1 antibody, Eif2ak1 antibody, Eukaryotic translation initiation factor 2 alpha kinase 1 antibody, Eukaryotic translation initiation factor 2-alpha kinase 1 antibody, HCR antibody, Heme controlled repressor antibody, Heme regulated eukaryotic initiation factor eIF 2 alpha kinase antibody, Heme regulated inhibitor antibody, Heme regulated initiation factor 2 alpha kinase antibody, Heme regulated repressor antibody, Heme sensitive initiation factor 2a kinase antibody, Heme-controlled repressor antibody, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody, Heme-regulated inhibitor antibody, Hemin sensitive initiation factor 2 alpha kinase antibody, Hemin-sensitive initiation factor 2-alpha kinase antibody, HRI antibody, KIAA1369 antibody, PRO1362 antibody
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UniProt
- Q9BQI3
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途径
- Hepatitis C
抗原
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