EMP2 抗体 (AA 22-66) (HRP)
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北京 101111
Quick Overview for EMP2 抗体 (AA 22-66) (HRP) (ABIN7151932)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-66
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原理
- EMP2 Antibody, HRP conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human Epithelial membrane protein 2 protein (22-66AA)
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亚型
- IgG
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anti-Epithelial Membrane Protein 2 (EMP2) (AA 22-66) antibody
EMP2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) antibodyEMP2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) (AA 100-129) antibodyEMP2 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) (C-Term) antibodyEMP2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) (Middle Region) antibodyEMP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) (AA 100-129), (C-Term) antibodyEMP2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB32736 unconjugated
anti-Epithelial Membrane Protein 2 (EMP2) (Middle Region) antibodyEMP2 适用: 人, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- EMP2 (Epithelial Membrane Protein 2 (EMP2))
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别名
- EMP2
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背景
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Background: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).
Aliases: EMP 2 antibody, EMP-2 antibody, EMP2 antibody, EMP2_HUMAN antibody, Epithelial membrane protein 2 antibody, Protein XMP antibody
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UniProt
- P54851
抗原
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