PKMYT1 抗体 (pThr495)
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- 抗原 See all PKMYT1 抗体
- PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))
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抗原表位
- pThr495
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKMYT1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human PKMYT1 around the phosphorylation site of Thr495
- 亚型
- IgG
- Top Product
- Discover our top product PKMYT1 Primary Antibody
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anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (pThr495) antibody
PKMYT1 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 1-499) antibodyPKMYT1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 400-499) antibodyPKMYT1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 900-1101) antibodyPKMYT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 49-98) antibodyPKMYT1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) antibodyPKMYT1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (pSer83) antibodyPKMYT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 1-499) antibodyPKMYT1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 452-482), (C-Term) antibodyPKMYT1 适用: 人 WB 宿主: 兔 Polyclonal RB09867 unconjugated
anti-Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1) (AA 114-143), (N-Term) antibodyPKMYT1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB34667 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))
- 别名
- PKMYT1 (PKMYT1 产品)
- 别名
- MYT1 antibody, 6230424P17 antibody, AW209059 antibody, Myt1 antibody, RGD1305434 antibody, myt1 antibody, protein kinase, membrane associated tyrosine/threonine 1 antibody, protein kinase, membrane associated tyrosine/threonine 1 S homeolog antibody, PKMYT1 antibody, pkmyt1 antibody, Pkmyt1 antibody, pkmyt1.S antibody
- 背景
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Synonyms: Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Background: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
- 基因ID
- 2475
- 途径
- Mitotic G1-G1/S Phases, M Phase
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