TRIM33 抗体 (AA 1-273) (Biotin)
Quick Overview for TRIM33 抗体 (AA 1-273) (Biotin) (ABIN7151259)
抗原
See all TRIM33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-273
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- TRIM33 (Tripartite Motif Containing 33 (TRIM33))
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别名
- TRIM33
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背景
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Background: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Aliases: 8030451N04Rik antibody, AI413936 antibody, cb1085 antibody, DKFZp586K1123 antibody, E3 ubiquitin-protein ligase TRIM33 antibody, EC 6.3.2.- antibody, Ectodermin antibody, Ectodermin homolog antibody, FLJ11429 antibody, FLJ32925 antibody, id:ibd2175 antibody, MGC136680 antibody, mKIAA1113 antibody, OTTHUMP00000013662 antibody, OTTHUMP00000013663 antibody, Protein Rfg7 antibody, PTC7 antibody, Ret fused gene 7 antibody, RET-fused gene 7 protein antibody, RFG7 antibody, Rfg7 protein antibody, TF1G antibody, TIF1 gamma antibody, TIF1-gamma antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, Transcription intermediary factor 1-gamma antibody, Transcriptional intermediary factor 1 gamma antibody, TRI33_HUMAN antibody, trim33 antibody, Tripartite motif containing 33 antibody, Tripartite motif containing 33 protein antibody, tripartite motif-containing 33 antibody, Tripartite motif-containing protein 33 antibody, wu:fc17f10 antibody, zgc:136680 antibody
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UniProt
- Q9UPN9
抗原
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