NHLRC1 抗体 (AA 86-395) (HRP)
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北京 101111
Quick Overview for NHLRC1 抗体 (AA 86-395) (HRP) (ABIN7151091)
抗原
See all NHLRC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 86-395
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原理
- NHLRC1 Antibody, HRP conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)
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亚型
- IgG
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anti-NHL Repeat Containing 1 (NHLRC1) (AA 1-280) antibody
NHLRC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) (AA 137-246) antibodyNHLRC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G6 unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) (AA 86-395) antibodyNHLRC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) (AA 1-280) antibodyNHLRC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NHL Repeat Containing 1 (NHLRC1) antibodyNHLRC1 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- NHLRC1 (NHL Repeat Containing 1 (NHLRC1))
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别名
- NHLRC1
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背景
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Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
Aliases: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B
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UniProt
- Q6VVB1
抗原
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