RFX6 抗体 (AA 1-260) (HRP)
Quick Overview for RFX6 抗体 (AA 1-260) (HRP) (ABIN7150388)
抗原
See all RFX6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-260
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human DNA-binding protein RFX6 protein (1-260AA)
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亚型
- IgG
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anti-Regulatory Factor X 6 (RFX6) (AA 1-928) antibody
RFX6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Factor X 6 (RFX6) (AA 1-260) antibodyRFX6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Factor X 6 (RFX6) antibodyRFX6 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Regulatory Factor X 6 (RFX6) (AA 1-928) antibodyRFX6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Regulatory Factor X 6 (RFX6) (Middle Region) antibodyRFX6 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 大鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RFX6 (Regulatory Factor X 6 (RFX6))
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别名
- RFX6
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背景
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Background: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).
Aliases: RFX6 antibody, RFXDC1 antibody, DNA-binding protein RFX6 antibody, Regulatory factor X 6 antibody, Regulatory factor X domain-containing protein 1 antibody
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UniProt
- Q8HWS3
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途径
- Carbohydrate Homeostasis
抗原
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