DISC1 抗体 (AA 99-325) (FITC)
Quick Overview for DISC1 抗体 (AA 99-325) (FITC) (ABIN7150094)
抗原
See all DISC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 99-325
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA)
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DISC1 (Disrupted in Schizophrenia 1 (DISC1))
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别名
- DISC1
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背景
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Background: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Aliases: C1orf136 antibody, DISC1 antibody, DISC1_HUMAN antibody, Disrupted in schizophrenia 1 antibody, Disrupted in schizophrenia 1 protein antibody, KIAA0457 antibody, RP4-730B13.1 antibody, SCZD9 antibody
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UniProt
- Q9NRI5
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途径
- Regulation of Cell Size
抗原
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