DLG5 抗体 (AA 1580-1704)
Quick Overview for DLG5 抗体 (AA 1580-1704) (ABIN7150080)
抗原
See all DLG5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1580-1704
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Disks large homolog 5 protein (1580-1704AA)
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亚型
- IgG
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anti-Discs, Large Homolog 5 (DLG5) (AA 1722-1905) antibody
DLG5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 5 (DLG5) (AA 1724-1917) antibodyDLG5 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 5 (DLG5) (AA 1708-1809) antibodyDLG5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A5 unconjugated
anti-Discs, Large Homolog 5 (DLG5) (AA 1708-1809) antibodyDLG5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DLG5 (Discs, Large Homolog 5 (DLG5))
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别名
- DLG5
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背景
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Background: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons, regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Aliases: Discs large homolog 5 (Drosophila) antibody, Discs large homolog 5 antibody, Discs large protein LP DLG antibody, Discs large protein P dlg antibody, Discs large protein P-dlg antibody, Disks large homolog 5 antibody, DLG 5 antibody, DLG5 antibody, DLG5_HUMAN antibody, KIAA0583 antibody, Large type of P DLG antibody, LP DLG antibody, P DLG5 antibody, PDLG antibody, Placenta and prostate DLG antibody
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UniProt
- Q8TDM6
抗原
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