NCK1 抗体 (AA 58-377)
Quick Overview for NCK1 抗体 (AA 58-377) (ABIN7149352)
抗原
See all NCK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-377
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交叉反应
- 人, 大鼠
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纯化方法
- Antigen Affinity purified
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免疫原
- Recombinant Human Cytoplasmic protein NCK1 protein (58-377AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- NCK1 (NCK Adaptor Protein 1 (NCK1))
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别名
- NCK1
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背景
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Background: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Aliases: Cytoplasmic protein NCK1 antibody, Melanoma Nck protein antibody, MGC12668 antibody, NCK 1 antibody, NCK adaptor protein 1 antibody, NCK alpha antibody, NCK antibody, NCK tyrosine kinase antibody, Nck-1 antibody, NCK1 antibody, NCK1_HUMAN antibody, NCKalpha antibody, Non catalytic region of tyrosine kinase antibody, SH2/SH3 adaptor protein NCK alpha antibody, SH2/SH3 adaptor protein NCK-alpha antibody
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UniProt
- P16333
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途径
- TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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