CREB3 抗体 (AA 1-230)
Our Local Distributor
北京 101111
Quick Overview for CREB3 抗体 (AA 1-230) (ABIN7148815)
抗原
See all CREB3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-230
-
原理
- CREB3 Antibody
-
纯化方法
- Antigen Affinity purified
-
免疫原
- Recombinant Human Cyclic AMP-responsive element-binding protein 3 protein (1-230AA)
-
亚型
- IgG
-
-
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 273-371) antibody
CREB3 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-230) antibodyCREB3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-371) antibodyCREB3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 311-344), (C-Term) antibodyCREB3 适用: 人 WB 宿主: 兔 Polyclonal RB50244 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (C-Term) antibodyCREB3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 76-87) antibodyVerified CREB3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 180-229) antibodyCREB3 适用: 人, Cow, 犬, Pig, 兔, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 247-296) antibodyCREB3 适用: 人, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))
-
别名
- CREB3
-
背景
-
Background: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells. Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It\\\'s transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5\\\'-GTGACGT[AG][AG]-3\\\') and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5\\\'-CCAC[GA]-3\\\'half of ERSE II (5\\\'-ATTGG-N-CCACG-3\\\'). Associates with chromatin to the HERPUD1 promoter.
Aliases: CREB3 antibody, LZIPCyclic AMP-responsive element-binding protein 3 antibody, CREB-3 antibody, cAMP-responsive element-binding protein 3 antibody, Leucine zipper protein antibody, Luman antibody, Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 antibody, N-terminal Luman antibody, Transcriptionally active form)] antibody
-
UniProt
- O43889
-
途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response
抗原
-
