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Cullin 4A 抗体 (AA 1-61) (FITC)

This anti-Cullin 4A antibody is a 兔 多克隆 antibody detecting Cullin 4A in . Suitable for 人.
产品编号 ABIN7148755
发货至: 中国

Quick Overview for Cullin 4A 抗体 (AA 1-61) (FITC) (ABIN7148755)

抗原

See all Cullin 4A (CUL4A) 抗体
Cullin 4A (CUL4A)

适用

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宿主

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克隆类型

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多克隆

标记

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This Cullin 4A antibody is conjugated to FITC

应用范围

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  • 抗原表位

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    AA 1-61

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Cullin-4A protein (1-61AA)

    亚型

    IgG
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    Cullin 4A (CUL4A)

    别名

    CUL4A

    背景

    Background: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

    Aliases: 2810470J21Rik antibody, AW495282 antibody, CUL 4A antibody, CUL-4A antibody, Cul4a antibody, Cul4a protein antibody, CUL4A_HUMAN antibody, Cullin-4A antibody, MGC36573 antibody, MGC64071 antibody

    UniProt

    Q13619
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