CNOT1 抗体 (AA 604-867) (FITC)
Quick Overview for CNOT1 抗体 (AA 604-867) (FITC) (ABIN7147091)
抗原
See all CNOT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 604-867
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 604-867) antibody
CNOT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 2137-2376) antibodyCNOT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 595-744) antibodyCNOT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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别名
- CNOT1
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背景
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Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Aliases: CNOT1 antibody, CDC39 antibody, KIAA1007 antibody, NOT1 antibody, AD-005CCR4-NOT transcription complex subunit 1 antibody, CCR4-associated factor 1 antibody, Negative regulator of transcription subunit 1 homolog antibody, NOT1H antibody, hNOT1 antibody
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UniProt
- A5YKK6
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途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
抗原
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