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CAMK1 抗体 (AA 166-265) (HRP)

This anti-CAMK1 antibody is a 兔 多克隆 antibody detecting CAMK1 in ELISA. Suitable for 人.
产品编号 ABIN7146431
发货至: 中国

Quick Overview for CAMK1 抗体 (AA 166-265) (HRP) (ABIN7146431)

抗原

See all CAMK1 抗体
CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

适用

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宿主

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克隆类型

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多克隆

标记

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This CAMK1 antibody is conjugated to HRP

应用范围

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ELISA
  • 抗原表位

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    AA 166-265

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Calcium/calmodulin-dependent protein kinase type 1 protein (166-265AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

    别名

    CAMK1

    背景

    Background: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \'Ser-694\', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \'Ser-91\', \'Ser-92\', \'Ser-93\' and \'Ser-294\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \'Ser-259\' and \'Ser-498\' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on \'Ser-276\' and \'Ser-295\'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

    Aliases: Calcium / calmodulin dependent protein kinase 1 antibody, Calcium / calmodulin dependent protein kinase I antibody, Calcium / calmodulin dependent protein kinase type 1 antibody, Calcium/calmodulin dependent protein kinase 1 antibody, Calcium/calmodulin dependent protein kinase I antibody, Calcium/calmodulin dependent protein kinase type 1 antibody, Calcium/calmodulin-dependent protein kinase type 1 antibody, CaM K1 antibody, CaM KI antibody, CaM kinase 1 alpha antibody, CAM kinase 1 antibody, CaM kinase I alpha antibody, CaM kinase I antibody, CaM-KI antibody, CaMK 1 antibody, CAMK I antibody, CaMK1 alpha antibody, CAMK1 antibody, CAMK1 PEN antibody, CaMKI alpha antibody, CaMKI-alpha antibody, KCC1A_HUMAN antibody, MGC120317 antibody, MGC120318 antibody

    UniProt

    Q14012

    途径

    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Smooth Muscle Cell Migration
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