CALCOCO1 抗体 (AA 462-691)
Quick Overview for CALCOCO1 抗体 (AA 462-691) (ABIN7146346)
抗原
See all CALCOCO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 462-691
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human Calcium-binding and coiled-coil domain-containing protein 1 protein (462-691AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))
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别名
- CALCOCO1
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背景
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Background: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Aliases: CALCOCO1 antibody, KIAA1536 antibody, PP13275 antibody, UNQ2436/PRO4996Calcium-binding and coiled-coil domain-containing protein 1 antibody, Calphoglin antibody, Coiled-coil coactivator protein antibody, Sarcoma antigen NY-SAR-3 antibody
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UniProt
- Q9P1Z2
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Chromatin Binding
抗原
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