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ZNF207 抗体 (AA 206-463)

This 兔 多克隆 anti-ZNF207 antibody specifically detects ZNF207 in ELISA 和 IF. The antibody is reactive with 人 samples.
产品编号 ABIN7145868
发货至: 中国
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Quick Overview for ZNF207 抗体 (AA 206-463) (ABIN7145868)

抗原

See all ZNF207 抗体
ZNF207 (Zinc Finger Protein 207 (ZNF207))

适用

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宿主

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克隆类型

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多克隆

标记

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This ZNF207 antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF)
  • 抗原表位

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    AA 206-463

    原理

    ZNF207 Antibody

    纯化方法

    Protein G purified

    纯度

    >95 %

    免疫原

    Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    ZNF207 (Zinc Finger Protein 207 (ZNF207))

    别名

    ZNF207

    背景

    Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

    Aliases: Zinc finger protein 207 antibody, ZN207_HUMAN antibody, ZNF 207 antibody, ZNF207 antibody

    UniProt

    O43670
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