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JMJD6 抗体 (AA 1-320)

This 兔 多克隆 anti-JMJD6 antibody specifically detects JMJD6 in ELISA 和 IHC. The antibody is reactive with 人 samples.
产品编号 ABIN7145557
发货至: 中国
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Quick Overview for JMJD6 抗体 (AA 1-320) (ABIN7145557)

抗原

See all JMJD6 抗体
JMJD6 (Jumonji Domain Containing 6 (JMJD6))

适用

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宿主

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克隆类型

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多克隆

标记

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This JMJD6 antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    AA 1-320

    原理

    JMJD6 Antibody

    纯化方法

    Antigen Affinity Purified

    免疫原

    Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    JMJD6 (Jumonji Domain Containing 6 (JMJD6))

    别名

    JMJD6

    背景

    Background: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at \\\'Arg-2\\\' (H3R2me) and histone H4 at \\\'Arg-3\\\' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

    Aliases: Apoptotic cell clearance receptor antibody, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody, Histone arginine demethylase JMJD6 antibody, JmjC domain-containing protein 6 antibody, JMJD 6 antibody, JMJD6 antibody, JMJD6_HUMAN antibody, Jumonji domain containing 6 antibody, Jumonji domain-containing protein 6 antibody, KIAA0585 antibody, Lysyl-hydroxylase JMJD6 antibody, Peptide-lysine 5-dioxygenase JMJD6 antibody, Phosphatidylserine receptor antibody, Protein PTDSR antibody, PSR antibody, PTDSR 1 antibody, PTDSR antibody, PTDSR1 antibody

    UniProt

    Q6NYC1
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