Asporin 抗体 (AA 33-380) (FITC)
Quick Overview for Asporin 抗体 (AA 33-380) (FITC) (ABIN7144763)
抗原
See all Asporin (ASPN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-380
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Asporin protein (33-380AA)
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Asporin (ASPN)
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别名
- ASPN
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背景
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Background: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Aliases: ASPN antibody, ASPN protein antibody, ASPN_HUMAN antibody, Asporin (LRR class 1) antibody, Asporin antibody, Asporin proteoglycan antibody, FLJ20129 antibody, LRR class 1 antibody, Periodontal ligament associated protein 1 antibody, Periodontal ligament-associated protein 1 antibody, PLAP 1 antibody, PLAP-1 antibody, PLAP1 antibody, SLRR 1C antibody, SLRR1C antibody, Small leucine rich protein 1C antibody
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UniProt
- Q9BXN1
抗原
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