ALOX12 抗体 (AA 508-658)
Quick Overview for ALOX12 抗体 (AA 508-658) (ABIN7144528)
抗原
See all ALOX12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 508-658
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Arachidonate 12-lipoxygenase, 12S-type protein (508-658AA)
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亚型
- IgG
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ALOX12 (Arachidonate 12-Lipoxygenase (ALOX12))
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别名
- ALOX12
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背景
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Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Aliases: 12 LOX antibody, 12(S) lipoxygenase antibody, 12-lipoxygenase antibody, 12LO antibody, 12S LOX antibody, 12S-lipoxygenase antibody, 12S-LOX antibody, 12S-type antibody, Alox12 antibody, Arachidonate 12 lipoxygenase antibody, Arachidonate 12 lipoxygenase, 12S type antibody, Arachidonate 12-lipoxygenase antibody, Arachidonate 12-oxidoreductase antibody, Lipoxin synthase 12-LO antibody, LOG12 antibody, LOX12_HUMAN antibody, P-12LO antibody, Platelet 12-LOX antibody, Platelet type lipoxygenase 12 antibody, platelet-type 12-lipoxygenase antibody, Platelet-type lipoxygenase 12 antibody
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UniProt
- P18054
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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