DCLRE1B 抗体 (AA 345-493)
Quick Overview for DCLRE1B 抗体 (AA 345-493) (ABIN7142656)
抗原
See all DCLRE1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 345-493
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human 5' exonuclease Apollo protein (345-493AA)
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亚型
- IgG
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anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 208-236) antibody
DCLRE1B 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB26835 unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (C-Term) antibodyDCLRE1B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 323-532) antibodyDCLRE1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
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别名
- DCLRE1B
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背景
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Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Aliases: DCLRE1B antibody, SNM1B5' exonuclease Apollo antibody, EC 3.1.-.- antibody, DNA cross-link repair 1B protein antibody, SNM1 homolog B antibody, SNMIB antibody, hSNM1B antibody
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UniProt
- Q9H816
抗原
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