PSMD1 抗体 (Regulatory Subunit 10)
Quick Overview for PSMD1 抗体 (Regulatory Subunit 10) (ABIN7142198)
抗原
See all PSMD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-226, Regulatory Subunit 10
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)
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亚型
- IgG
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anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (AA 251-300) antibody
PSMD1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 斑马鱼, Pig, 小鸡, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) antibodyPSMD1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (AA 1-110) antibodyPSMD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (AA 107-156) antibodyPSMD1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (AA 794-953) antibodyPSMD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (N-Term) antibodyPSMD1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 斑马鱼, 豚鼠, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1) (N-Term) antibodyPSMD1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))
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别名
- PSMD1
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背景
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Background: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Aliases: 26S proteasome non-ATPase regulatory subunit 10 antibody, 26S proteasome regulatory subunit p28 antibody, Ankyrin repeat protein antibody, dJ889N15.2 antibody, Gankyrin antibody, Hepatocellular carcinoma-associated protein p28 II antibody, p28 antibody, p28(GANK) antibody, Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody, Proteasome 26S S10 antibody, PSD10_HUMAN antibody, Psmd10 antibody
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UniProt
- O75832
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
抗原
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