OAS3 抗体 (AA 424-565)
Quick Overview for OAS3 抗体 (AA 424-565) (ABIN7142174)
抗原
See all OAS3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 424-565
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)
-
亚型
- IgG
-
-
anti-2'-5' Oligoadenylate Synthetase 3 (OAS3) antibody
OAS3 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-2'-5' Oligoadenylate Synthetase 3 (OAS3) antibodyOAS3 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-2'-5' Oligoadenylate Synthetase 3 (OAS3) (AA 320-620) antibodyOAS3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-2'-5' Oligoadenylate Synthetase 3 (OAS3) (AA 1056-1087), (C-Term) antibodyOAS3 适用: 人 WB 宿主: 兔 Polyclonal RB1945 unconjugated
-
-
应用备注
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
-
别名
- OAS3
-
背景
-
Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2\'-5\'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Aliases: (2-5'')oligo(A) synthase 3 antibody, 2 5' oligo(A) synthetase 3 antibody, 2 5'LIGO antibody, 2 5A synthetase 3 antibody, 2''-5''-oligoadenylate synthase 3 antibody, 2-5A synthase 3 antibody, MGC133260 antibody, OAS3 2' 5' oligoadenylate synthetase 3, 100 kDa antibody, OAS3 antibody, OAS3_HUMAN antibody, p100 antibody, p100 OAS antibody, p100OAS antibody
-
UniProt
- Q9Y6K5
-
途径
- Hepatitis C
抗原
-
