UBE2O 抗体 (AA 10-277)
Quick Overview for UBE2O 抗体 (AA 10-277) (ABIN7141984)
抗原
See all UBE2O 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-277
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交叉反应
- 人
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纯化方法
- Antigen Affinity Purified
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免疫原
- Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA)
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亚型
- IgG
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anti-Ubiquitin-Conjugating Enzyme E2O (UBE2O) (AA 1073-1292) antibody
UBE2O 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2O (UBE2O) (AA 361-470) antibodyUBE2O 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2O (UBE2O) (AA 1-741) antibodyUBE2O 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2O (UBE2O) (AA 1079-1128) antibodyUBE2O 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 猴, Pig, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))
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别名
- UBE2O
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背景
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Background: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate \\\'Lys-63\\\'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Aliases: E2 230K antibody, EC=6.3.2.19 antibody, FLJ12878 antibody, KIAA1734 antibody, Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme antibody, RP23 193A16.5 antibody, UBE2O antibody, UBE2O_HUMAN antibody, Ubiquitin carrier protein O antibody, Ubiquitin conjugating enzyme E2 O antibody, Ubiquitin conjugating enzyme E2 of 230 kDa antibody, ubiquitin conjugating enzyme E2O antibody, Ubiquitin protein ligase O antibody, Ubiquitin-conjugating enzyme E2 O antibody, Ubiquitin-conjugating enzyme E2 of 230 kDa antibody, Ubiquitin-conjugating enzyme E2-230K antibody, Ubiquitin-protein ligase O antibody
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UniProt
- Q9C0C9
抗原
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