LexA (AA 1-202) 抗体
Quick Overview for LexA (AA 1-202) 抗体 (ABIN7141555)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-202
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原理
- lexA Antibody
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Escherichia coli LexA repressor protein (1-202AA)
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亚型
- IgG
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anti-LexA (DNA Binding Domain) antibody
适用: 化学剂 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LexA
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背景
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Background: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5\\\'-CTGTATATATATACAG-3\\\'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
Aliases: lexA antibody, exrA antibody, spr antibody, tsl antibody, umuA antibody, b4043 antibody, JW4003LexA repressor antibody, EC 3.4.21.88 antibody
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UniProt
- P0A7C2
抗原
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