BotA (AA 1-436) 抗体 (Biotin)
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北京 101111
Quick Overview for BotA (AA 1-436) 抗体 (Biotin) (ABIN7141049)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-436
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原理
- botA Antibody, Biotin conjugated
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纯化方法
- Protein G purified
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纯度
- >95 %
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免疫原
- Recombinant Clostridium botulinum Botulinum neurotoxin type A protein (1-436AA)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BotA
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背景
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Background: Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
Aliases: botA antibody, atx antibody, bonTBotulinum neurotoxin type A antibody, BoNT/A antibody, Bontoxilysin-A antibody, BOTOX antibody, Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain antibody, LC antibody, EC 3.4.24.69), Botulinum neurotoxin A heavy chain antibody, HC)] antibody
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UniProt
- P0DPI0
抗原
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