RABAC1 抗体 (AA 16-299)
Quick Overview for RABAC1 抗体 (AA 16-299) (ABIN7140908)
抗原
See all RABAC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 16-299
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交叉反应
- Candida albicans
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)
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亚型
- IgG
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anti-Rab Acceptor 1 (Prenylated) (RABAC1) (AA 1-77) antibody
RABAC1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2A4 unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))
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别名
- PRA1
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背景
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Background: Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
Aliases: PRA1 antibody, FBP1 antibody, CAALFM_C406980WA antibody, CaO19.10623 antibody, CaO19.3111 antibody, pH -regulated antigen PRA1 antibody, 58 kDa fibrinogen-binding mannoprotein antibody
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UniProt
- P87020
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途径
- Chromatin Binding
抗原
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