African Cassava Mosaic Virus (ACMV) AC1 (AA 1-358) 抗体

Background: Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5\'-TAATATTAC-3\' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5\'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3\'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities (By similarity).

Aliases: AC1 antibody, AL1 antibody, Replication-associated protein antibody, Rep antibody, EC 2.7.7.- antibody, EC 3.1.21.- antibody, 40.4 kDa protein antibody, Protein AC1 antibody, Protein AL1 antibody