PIK3R1/PIK3R3 抗体 (pTyr467)
Quick Overview for PIK3R1/PIK3R3 抗体 (pTyr467) (ABIN7139011)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr467
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of tyrosine 467 (L-Y(p)-E-E-Y) derived from Human PI3 Kinase p85/p55.
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亚型
- IgG
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anti-Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A) (pTyr199), (pTyr467) antibody
PIK3R3A 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))
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别名
- PIK3R1/PIK3R3
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背景
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Background:
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Stoyanov, B. et al. (1995) Science 269, 690-3.
Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.Aliases: p85, AGM7, p85-ALPHA, p55, p55-GAMMA
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UniProt
- P27986, Q92569
抗原
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