KRT8 抗体 (pSer74)
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- 抗原 See all KRT8 抗体
- KRT8 (Keratin 8 (KRT8))
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抗原表位
- pSer74
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KRT8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), ELISA
- 交叉反应
- 人
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- 免疫原
- Peptide sequence around phosphorylation site of serine 74 (L-L-S(p)-P-L) derived from Human Keratin 8 (CK8).
- 亚型
- IgG
- Top Product
- Discover our top product KRT8 Primary Antibody
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- 应用备注
- WB:1:500-1:1000, IF:1:100-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- KRT8 (Keratin 8 (KRT8))
- 别名
- KRT8 (KRT8 产品)
- 背景
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Background:
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
Nakamichi I, et al. (2002) Mol Biol Cell, 13(10): 3441-3451.
Prochasson P, et al. (2002) Nucleic Acids Res, 30(15): 3312-3322.
Pankov R, et al. (1994) Proc Natl Acad Sci U S A, 91(3): 873-877.
Thorey IS, et al. (1993) Mol Cell Biol, 13(11): 6742-6751Aliases: CARD2 antibody, CK 8 antibody, CK-8 antibody, CK8 antibody, CYK8 antibody, CYKER antibody, Cytokeratin endo A antibody, Cytokeratin-8 antibody, DreK8 antibody, EndoA antibody, K2C8 antibody, K2C8_HUMAN antibody, K8 antibody, Keratin 8 antibody, Keratin type II cytoskeletal 8 antibody, Keratin, type II cytoskeletal 8 antibody, Keratin-8 antibody, KO antibody, Krt 2.8 antibody, KRT8 antibody, MGC118110 antibody, MGC174782 antibody, MGC53564 antibody, MGC85764 antibody, sb:cb186 antibody, Type-II keratin Kb8 antibody
- UniProt
- P05787
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