Merlin 抗体 (pSer518)
Quick Overview for Merlin 抗体 (pSer518) (ABIN7138643)
抗原
See all Merlin (NF2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer518
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 518 (R-L-S(p)-M-E) derived from Human Merlin.
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亚型
- IgG
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anti-Neurofibromin 2 (NF2) (AA 477-576) antibody
NF2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 230-414) antibodyNF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-239) antibodyNF2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-311) antibodyNF2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-507) antibodyNF2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-50), (pSer10) antibodyNF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, Cow, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 65-95), (N-Term) antibodyNF2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB19187 unconjugated
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应用备注
- WB:1:500-1:1000, IF:1:100-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Merlin (NF2) (Neurofibromin 2 (NF2))
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别名
- NF2
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背景
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Background:
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.
Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol , 25: 2384 - 2394.
Hi-Su Yang, et al. (2006) Cancer Res , 66: 2708 - 2715.
R Bohni, et al. (1994) J. Biol. Chem , 269: 14541 - 14545.
Adam J. Ratner, et al. (2001) J. Biol. Chem , 276: 19267 - 19275.Aliases: ACN antibody, BANF antibody, Bilateral acoustic neuroma antibody, MERL_HUMAN antibody, Merlin antibody, Moesin ezrin radixin like protein antibody, Moesin ezrin radizin like antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromatosis 2 antibody, Neurofibromatosis type 2 antibody, Neurofibromatosis2 antibody, Neurofibromin 2 antibody, Neurofibromin-2 antibody, Neurofibromin2 antibody, NF 2 antibody, Nf2 antibody, SCH antibody, Schwannomerlin antibody, Schwannomin antibody
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UniProt
- P35240
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途径
- Cell-Cell Junction Organization
抗原
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