ATR 抗体 (pSer428)
Quick Overview for ATR 抗体 (pSer428) (ABIN7138618)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer428
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交叉反应
- 人
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 428 (G-I-S(p)-P-K) derived from Human ATR.
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亚型
- IgG
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anti-ATR serine/threonine kinase (ATR) (pThr1989) antibody
ATR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 366-550) antibodyATR 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3G6D2 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2645) antibodyATR 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2644) antibodyATR 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3F2 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2405-2644) antibodyATR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (pSer428) antibodyATR 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2644) antibodyATR 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) antibodyATR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (Ser16) antibodyATR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2644) antibodyATR 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1E9 unconjugated
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应用备注
- IHC:1:50-1:100,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
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Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Aliases: Ataxia telangiectasia and Rad3 related antibody, Ataxia telangiectasia and Rad3-related protein antibody, ATR antibody, ATR_HUMAN antibody, FCTCS antibody, FRAP Related Protein 1 antibody, FRAP-related protein 1 antibody, FRP1 antibody, MEC1 antibody, MEC1 mitosis entry checkpoint 1 homolog antibody, Protein kinase ATR antibody, RAC3 antibody, Rad3 related protein antibody, SCKL antibody, SCKL1 antibody, Serine/threonine protein kinase ATR antibody, Serine/threonine-protein kinase ATR antibody
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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