FOXO1 抗体 (pSer256)
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- 抗原 See all FOXO1 抗体
- FOXO1 (Forkhead Box O1 (FOXO1))
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抗原表位
- pSer256
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FOXO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- 免疫原
- Peptide sequence around phosphorylation site of serine 256 (A-A-S(p)-M-D) derived from Human FKHR.
- 亚型
- IgG
- Top Product
- Discover our top product FOXO1 Primary Antibody
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anti-Forkhead Box O1 (FOXO1) (AA 165-270) antibody
FOXO1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 小鸡 WB, ELISA, IF (p), IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 333-557) antibodyFOXO1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人 WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人, 小鼠 WB, IHC, ELISA, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 452-555) antibodyFOXO1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A10 unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 556-655) antibodyFOXO1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Forkhead Box O1 (FOXO1) (pSer256) antibodyFOXO1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O1 (FOXO1) antibodyFOXO1 适用: 人, 小鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Forkhead Box O1 (FOXO1) (AA 222-469) antibodyFOXO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- FOXO1 (Forkhead Box O1 (FOXO1))
- 别名
- FOXO1 (FOXO1 产品)
- 背景
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Background:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells.
Guo S., Rena G., Cichy S., He X., Cohen P., Unterman T.J. Biol. Chem. 274:17184-17192(1999)Zhang X., Gan L., Pan H., Guo S., He X., Olson S.T., Mesecar A., Adam S., Unterman T.G.J. Biol. Chem. 277:45276-45284(2002)Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.Proc. Natl. Acad. Sci. U.S.A. 101:10042-10047(2004)Aliases: FKH 1 antibody; FKH1 antibody; FKHR antibody; Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody; Forkhead box O1 antibody; Forkhead box protein O1 antibody; Forkhead box protein O1A antibody; Forkhead in rhabdomyosarcoma antibody; Forkhead; Drosophila; homolog of; in rhabdomyosarcoma antibody; FoxO transcription factor antibody; foxo1 antibody; FOXO1_HUMAN antibody; FOXO1A antibody; OTTHUMP00000018301 antibody
- UniProt
- Q12778
- 途径
- PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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