CARM1 抗体 (pSer228)
Quick Overview for CARM1 抗体 (pSer228) (ABIN7138493)
抗原
See all CARM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer228
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原理
- Phospho-CARM1 (Ser228) Antibody
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 228(V-K-S(p)-N-N) derived from Human CARM1.
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亚型
- IgG
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anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 409-608) antibody
CARM1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) antibodyCARM1 适用: 人, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3H2 unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 346-377) antibodyCARM1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 209-379) antibodyCARM1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) antibodyCARM1 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 346-377) antibodyCARM1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB09614 unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 411-510) antibodyCARM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (N-Term) antibodyCARM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 284-381) antibodyCARM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G9 unconjugated
anti-Coactivator-Associated Arginine Methyltransferase 1 (CARM1) (AA 550-585), (C-Term) antibodyCARM1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬 WB, IHC, IF, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))
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别名
- CARM1
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背景
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Background:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs
Aliases: PRMT4
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UniProt
- A6NN38
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of fat Cell Differentiation
抗原
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