FOXO4 抗体 (pSer197)
Quick Overview for FOXO4 抗体 (pSer197) (ABIN7138463)
抗原
See all FOXO4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer197
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 197 (A-A-S(p)-M-D) derived from Human AFX.
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亚型
- IgG
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应用备注
- WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FOXO4 (Forkhead Box O4 (FOXO4))
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别名
- FOXO4
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背景
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Background: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Di Maira G, et al. (2005)Cell Death Differ, 12(6): 668-77.
Essers MA, et al. EMBO J 2004 Nov. 11.
Brownawell AM, (2001) Mol Cell Biol, 21(10): 3534-46.
Kops GJ, et al. (1999) Nature, 398(6728): 630-4.Aliases: AFX antibody, AFX1 antibody, Afxh antibody, ALL1-fused gene from X chromosome antibody, Fork head domain transcription factor AFX1 antibody, Forkhead box O4 antibody, Forkhead box protein O4 antibody, FOXO 4 antibody, Foxo4 antibody, FOXO4_HUMAN antibody, MGC117660 antibody, MGC120490 antibody, Mixed lineage leukemia, translocated to, 7 antibody, MLLT7 antibody, Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila), translocated to, 7 antibody, Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody, RGD1561201 antibody
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UniProt
- P98177
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途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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