SPATA13 抗体
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北京 101111
Quick Overview for SPATA13 抗体 (ABIN7131154)
抗原
See all SPATA13 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SPATA13 Antibody
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交叉反应
- 小鼠
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纯化方法
- Antigen affinity purification
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免疫原
- Fusion protein of Human SPATA13
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亚型
- IgG
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anti-Spermatogenesis Associated 13 (SPATA13) (AA 204-232) antibody
SPATA13 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27015 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- SPATA13 (Spermatogenesis Associated 13 (SPATA13))
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别名
- SPATA13
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背景
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Background: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.
Aliases: APC-stimulated guanine nucleotide exchange factor 2 antibody, ARHGEF29 antibody, Asef2 antibody, FLJ31208 antibody, RP11-307N16.3 antibody, Spata13 antibody, Spermatogenesis-associated protein 13 antibody, SPT13_HUMAN antibody
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UniProt
- Q96N96
抗原
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