Recombinant USP7 抗体
Quick Overview for Recombinant USP7 抗体 (ABIN7127535)
抗原
See all USP7 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human HAUSP / USP7
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 54-507) antibody
USP7 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 206-1102) antibodyUSP7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 1050-1100) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Internal Region) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 258-483) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 302-394), (C-Term) antibodyUSP7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 30-80) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5F11 unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 1060-1090), (C-Term) antibodyUSP7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4281 unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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别名
- USP7
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背景
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Background: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex, may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B, it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
Aliases: Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7), USP7, HAUSP
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UniProt
- Q93009
抗原
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