Recombinant LPAR1 抗体
Quick Overview for Recombinant LPAR1 抗体 (ABIN7127464)
抗原
See all LPAR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human EDG2
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亚型
- IgG
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anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (AA 281-364) antibody
LPAR1 适用: 人, 小鼠 WB, ELISA, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) antibodyLPAR1 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 1G6 unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (N-Term) antibodyLPAR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (AA 316-364) antibodyLPAR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (AA 342-359) antibodyLPAR1 适用: 人, 小鼠, 大鼠, 猴, Bat, 小鸡, Cow, 犬, Hamster, 马, Pig, 绵羊, 非洲爪蟾 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (Cytoplasmic Domain) antibodyLPAR1 适用: 人, 小鼠, 大鼠, 猴, Bat, 小鸡, Cow, 犬, Hamster, 马, Pig, 绵羊, 非洲爪蟾, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (N-Term) antibodyLPAR1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (N-Term) antibodyLPAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) (AA 5-54) antibodyLPAR1 适用: 人, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysophosphatidic Acid Receptor 1 (LPAR1) antibodyLPAR1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
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别名
- LPAR1
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背景
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Background: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA, this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
Aliases: Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2), LPAR1, EDG2 LPA1
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UniProt
- Q92633
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途径
- Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
抗原
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