Recombinant DGCR8 抗体
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北京 101111
Quick Overview for Recombinant DGCR8 抗体 (ABIN7127453)
抗原
See all DGCR8 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- DGCR8 Recombinant Monoclonal Antibody
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human DGCR8
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亚型
- IgG
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anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibody
KD Validated DGCR8 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1615 unconjugated Recombinant Antibody
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibodyDGCR8 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (C-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 180-229) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (N-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 豚鼠, 斑马鱼, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:5000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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别名
- DGCR8
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背景
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Background: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).
Aliases: Microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, DGCR8, C22orf12, DGCRK6, LP4941
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UniProt
- Q8WYQ5
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途径
- Regulatory RNA Pathways
抗原
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