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Recombinant DPP4 抗体

DPP4 适用: 人 IHC, ELISA 宿主: 兔 Monoclonal 6G7 unconjugated Recombinant Antibody
产品编号 ABIN7127398
发货至: 中国
  • 抗原 See all DPP4 抗体
    DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
    抗体类型
    Recombinant Antibody
    适用
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    克隆类型
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    单克隆
    标记
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    This DPP4 antibody is un-conjugated
    应用范围
    • 68
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    Immunohistochemistry (IHC), ELISA
    交叉反应
    纯化方法
    Affinity-chromatography
    免疫原
    A synthesized peptide derived from human CD26
    克隆位点
    6G7
    亚型
    IgG
    Top Product
    Discover our top product DPP4 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
    别名
    DPP4 (DPP4 产品)
    背景

    Background: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

    Aliases: Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form), Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)], DPP4, ADCP2 CD26

    UniProt
    P27487
    途径
    Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
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