Recombinant BUB1 抗体
Quick Overview for Recombinant BUB1 抗体 (ABIN7127373)
抗原
See all BUB1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Bub1
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亚型
- IgG
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anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibody
BUB1 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-130) antibodyBUB1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibodyBUB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C3-4C9 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-130) antibodyBUB1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A11C7 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 951-1085) antibodyBUB1 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 281-419) antibodyBUB1 适用: 人, 小鼠 WB, IF, IHC (p), ICC, FACS 宿主: 小鼠 Monoclonal 14H5 unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 1-1085) antibodyBUB1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 731-1085) antibodyBUB1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) (AA 256-577) antibodyBUB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) antibodyBUB1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
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别名
- BUB1
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背景
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Background: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Aliases: Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A), BUB1, BUB1L
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UniProt
- O43683
抗原
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