QKI 抗体
Quick Overview for QKI 抗体 (ABIN7127192)
抗原
See all QKI 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human QKI protein
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亚型
- IgG2
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anti-Protein Quaking (QKI) antibody
QKI 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Protein Quaking (QKI) (AA 1-341) antibodyQKI 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Quaking (QKI) (AA 1-341) antibodyQKI 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Quaking (QKI) (AA 1-341) antibodyQKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 unconjugated
anti-Protein Quaking (QKI) (AA 1-341) antibody (HRP)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 HRP
anti-Protein Quaking (QKI) (AA 1-341) antibody (FITC)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 FITC
anti-Protein Quaking (QKI) (AA 1-341) antibody (Biotin)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 Biotin
anti-Protein Quaking (QKI) (AA 1-341) antibody (PE)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 PE
anti-Protein Quaking (QKI) (AA 1-341) antibody (APC)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 APC
anti-Protein Quaking (QKI) (AA 1-341) antibody (PerCP)QKI 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S147-6 PerCP
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应用备注
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Known_Application: ELISA (concentration assay dependent), Flow Cytometry (1-2 μg/million cells),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: U87, HeLa, K562 or MCF7 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- QKI (Protein Quaking (QKI))
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别名
- QKI
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背景
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Homolog of mouse quaking QKI KH domain RNA binding protein, HQK1, Protein quaking, QK1, QK3, QKI, QKI1, Quaking homolog KH domain RNA binding mouse, Quaking isoform 1, Quaking protein, RNA binding protein HQK,QKI / Protein Quaking
Cellular localisation: Nucleus. Cytoplasm. -
分子量
- 37.6kDa
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基因ID
- 9444, 510324
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UniProt
- Q96PU8
抗原
-
