TRIM24 抗体
Quick Overview for TRIM24 抗体 (ABIN7127116)
抗原
See all TRIM24 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- TIF1i±, also known as TRIM24, mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors. TIF1i± localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. TIF1i± is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. The TIF1i± gene, which maps to human chromosome 7q33, encodes two alternatively spliced transcripts. However, the full length nature of one variant has not been determined. A TIF1i± homolog (designated bonus) has been identified in Drosophila and is associated with several genes that are implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development, suggesting a conserved functional role for the protein throughout the course of evolution.
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交叉反应 (详细)
- Human
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human TRIM24 protein
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亚型
- IgG1
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or K562 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- TRIM24 (Tripartite Motif Containing 24 (TRIM24))
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别名
- TRIM24
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背景
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E3 ubiquitin protein ligase TRIM24, hTIF1, PTC6, RING finger protein 82, RNF82, TF1A, TIF1 alpha, Transcriptional intermediary factor 1 alpha, Tripartite motif-containing protein 24,TRIM24 / TIF1 alpha
Cellular localisation: Nucleus. Cytoplasm. Colocalizes with sites of active transcription. -
分子量
- 117kDa
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基因ID
- 8805, 490287
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UniProt
- O15164
抗原
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