CGRP 抗体 (AA 3-116)
Quick Overview for CGRP 抗体 (AA 3-116) (ABIN7127075)
抗原
See all CGRP (CALCA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-116
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特异性
- Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or i±-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or i²-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human Calcitonin protein (around aa 3-116) (exact sequence is proprietary)
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亚型
- IgG2b
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anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-141) antibody
CALCA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-130) antibodyCALCA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 52-141) antibodyCALCA 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-141) antibodyCALCA 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 65-130) antibodyCALCA 适用: 人, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-134) antibodyCALCA 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (Internal Region) antibodyCALCA 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 80-141) antibodyCALCA 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 85-116) antibodyCALCA 适用: 犬 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) antibodyCALCA 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4G1H7 unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1:10-1:20 for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human thyroid.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
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别名
- CALCA
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背景
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Alpha type CGRP, CALC1, calcitonin gene related peptide 1, CT, katacalcin (KC),Calcitonin
Cellular localisation: Cytoplasm. Secreted -
分子量
- 14.5kDa
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基因ID
- 796, 37058
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UniProt
- P01258
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途径
- Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
抗原
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