SPTAN1 抗体 (AA 2351-2475)
Quick Overview for SPTAN1 抗体 (AA 2351-2475) (ABIN7126980)
抗原
See all SPTAN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2351-2475
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特异性
- Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous i± and i² chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin i± I and spectrin i² I are present in erythrocytes, whereas spectrin i± II (also designated fodrin i±) and spectrin i² II (also designated fodrin i²) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin i± II, a neuronal cytoskeleton protein.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary))
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亚型
- IgG
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anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 950-1130) antibody
SPTAN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2071-2269) antibodySPTAN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) antibodySPTAN1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 1573-1742) antibodySPTAN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) antibodySPTAN1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2351-2475) antibodySPTAN1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal SPTAN1-3351 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 289-408) antibodySPTAN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 977-991) antibodySPTAN1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50708 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2351-2475) antibodySPTAN1 适用: 人 IHC, ELISA, Coat 宿主: 小鼠 Monoclonal SPTAN1-3352 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 1004-1181) antibodySPTAN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human colon or kidney tissues (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
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别名
- SPTAN1
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背景
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Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2,Fodrin / Alpha Spectrin II (SPTAN1) / NEAS
Cellular localisation: Cytoplasm -
分子量
- 240kDa
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基因ID
- 6709, 372331
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UniProt
- Q13813
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途径
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
抗原
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