SOX11 抗体 (AA 50-200)
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北京 101111
Quick Overview for SOX11 抗体 (AA 50-200) (ABIN7126963)
抗原
See all SOX11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 50-200
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特异性
- Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa50-200) of human SOX11 protein (exact sequence is proprietary)
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亚型
- IgG1
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anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 1-250) antibody
SOX11 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8D5D4 unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 1-250) antibodySOX11 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A6C10 unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 241-341) antibodySOX11 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) antibodySOX11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (N-Term) antibodySOX11 适用: 人, 大鼠, 小鼠, 豚鼠, 马, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 103-132) antibodySOX11 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 309-323) antibodyVerified SOX11 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (C-Term) antibodySOX11 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (N-Term) antibodySOX11 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 11 (SOX11) (AA 251-300) antibodySOX11 适用: 人, 大鼠, 小鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human tonsil or mantle cell lymphoma (MCL).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))
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别名
- SOX11
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背景
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SOX11, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, Transcription factor SOX-11,SOX11 (Mantle Cell Lymphoma Marker)
Cellular localisation: Nucleus. -
分子量
- 47kDa
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基因ID
- 6664, 432638
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UniProt
- P35716
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途径
- Tube Formation
抗原
-
