RORC 抗体
Quick Overview for RORC 抗体 (ABIN7126903)
抗原
See all RORC 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors RORi± and RORi³ are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50 % amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human RORC protein
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亚型
- IgG2a
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anti-RAR-Related Orphan Receptor C (RORC) (AA 212-461) antibody
RORC 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 200-212) antibodyVerified RORC 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (Middle Region) antibodyRORC 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (N-Term) antibodyRORC 适用: 人, 小鼠, 大鼠, Cow, 马, 豚鼠, 犬, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 412-517) antibodyRORC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 110-159) antibodyRORC 适用: 人, Cow, 马, 豚鼠, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50) antibodyRORC 适用: 人, 小鼠 WB, FACS 宿主: 小鼠 Monoclonal 4G419 unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-518) antibodyRORC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) (Modulating Domain) antibodyRORC 适用: 人 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAR-Related Orphan Receptor C (RORC) antibodyRORC 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RORC-2942 unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells) (3 % PFA-fixed cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: MOLT4 cells. Human lymphocytes. Human liver or skeletal muscle tissue.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- RORC (RAR-Related Orphan Receptor C (RORC))
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别名
- RORC
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背景
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Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR,ROR-gamma / RORC (RAR-related Orphan Receptor C)
Cellular localisation: Nuclear -
分子量
- 63kDa
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基因ID
- 6097
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UniProt
- P51449
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
抗原
-
