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MBNL3 抗体

This anti-MBNL3 antibody is a 小鼠 单克隆 antibody detecting MBNL3 in FACS. Suitable for 人.
产品编号 ABIN7126833
发货至: 中国

Quick Overview for MBNL3 抗体 (ABIN7126833)

抗原

See all MBNL3 抗体
MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

适用

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宿主

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小鼠

克隆类型

  • 26
单克隆

标记

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This MBNL3 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)
  • 特异性

    Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.

    交叉反应 (详细)

    Human

    纯化方法

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    免疫原

    Recombinant full-length human MBNL3 protein

    亚型

    IgG2b
  • 应用备注

    Known_Application: Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or MCF7 cells.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    储存液

    Azide free

    储存条件

    -20 °C,-80 °C

    储存方法

    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    有效期

    24 months
  • 抗原

    MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

    别名

    MBNL3

    背景

    CHCR, Cys3His CCG1 required protein, MBLX, MBLX39, Muscleblind like protein 3, Muscleblind like splicing regulator 3, Muscleblind-like X-linked protein, Protein HCHCR, RP23-98P13.1,MBNL3
    Cellular localisation: Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.

    分子量

    39kDa

    基因ID

    55796

    UniProt

    Q9NUK0

    途径

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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