TREM2 抗体 (AA 1-200)
Quick Overview for TREM2 抗体 (AA 1-200) (ABIN7126804)
抗原
See all TREM2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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特异性
- Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), known as Nasu-Hakola disease , is a recessively inherited disease where individuals display early-onset progressive dementia and bone cysts, which leads to death. Mutations in TYROBP (DAP12), which codes for a membrane receptor component in natural-killer and myeloid cells and mutations in triggering receptor expressed on myeloid cells-2 (TREM-2), correlate well to the pathology of PLOSL. TREM-2 is a cell surface receptor on human monocyte-derived dendritic cells that forms a receptor signaling complex with DAP12 and triggers activation of the immune response in macrophages and dendritic cells (DC). The TREM-2/DAP12 complex is a molecular promoter of upregulation of CC chemokine receptor 7, partial DC maturation, and DC survival through activation of protein tyrosine kinases and extracellular signal regulated kinase. The human chronic inflammatory TREM-2 gene maps to chromosome 6p21.1 and encodes a 230 amino acid protein.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-200) of human TREM2 protein (exact sequence is proprietary)
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亚型
- IgG
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anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-100) antibody
TREM2 适用: 小鼠, 人, 大鼠, Pig WB, ELISA, ICC, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-228) antibodyTREM2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-227) antibodyTREM2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (Internal Region) antibodyVerified TREM2 适用: 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 22-48), (N-Term) antibodyTREM2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB38661 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular) antibodyTREM2 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) antibodyTREM2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) antibody (PE)TREM2 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 78-18 PE
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-161) antibodyTREM2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular) antibody (PE)TREM2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal PE
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human small intestine, ovary or placenta.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
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别名
- TREM2
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背景
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TREM2, TREM2a, TREM2b, TREM2c, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2,TREM2 (Triggering Receptor Expressed On Myeloid Cells 2)
Cellular localisation: Cell surface. Secreted. -
分子量
- 40kDa (glycosylated), 26kDa (deglycosylated)
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基因ID
- 54209, 435295
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UniProt
- Q9NZC2
抗原
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