BCL11A 抗体
Quick Overview for BCL11A 抗体 (ABIN7126795)
抗原
See all BCL11A 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
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交叉反应 （详细）
- Human. Predicted to react in Mouse and Rat.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human BCLL1A protein
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亚型
- IgG2a
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anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-88) antibody
BCL11A 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (N-Term) antibodyBCL11A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 斑马鱼, 小鸡, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-230) antibodyBCL11A 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-89) antibodyBCL11A 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-243) antibodyBCL11A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) antibodyBCL11A 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (N-Term) antibodyBCL11A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-210) antibodyBCL11A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-88) antibodyBCL11A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-243) antibodyBCL11A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Expressed in all tissues except in cells of the B and T lineage.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
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别名
- BCL11A
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背景
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B cell CLL/lymphoma 11A isoform 2, B-cell lymphoma/leukemia 11A, C2H2 type zinc finger protein, COUP-TF-interacting protein 1, CTIP1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856, ZNF856,BCL11A / CTIP1 (Transcription Factor)
Cellular localisation: Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles. -
分子量
- 91.2kDa
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基因ID
- 53335, 370549
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UniProt
- Q9H165
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途径
- Regulation of Cell Size
抗原
-
