OTX2 抗体
Quick Overview for OTX2 抗体 (ABIN7126753)
抗原
See all OTX2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.
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交叉反应 （详细）
- Human. Predicted to react in Chick, Mouse, Rat, Xenopus and Zebrafish.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human full-lengthOTX2protein
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亚型
- IgG1
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anti-Orthodenticle Homeobox 2 (OTX2) antibody
OTX2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1H12C4B5 unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (N-Term) antibodyOTX2 适用: 人, 大鼠, 小鼠, 斑马鱼, 犬, 绵羊, 兔, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) antibodyOTX2 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (AA 1-297) antibodyOTX2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (AA 86-135) antibodyOTX2 适用: 人, 大鼠, 小鼠, 斑马鱼, 犬, 绵羊, 兔, 马, Cow, 豚鼠, Bat, Hamster, Pig, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (AA 140-280) antibodyOTX2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) antibodyOTX2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (AA 261-289), (C-Term) antibodyOTX2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17482 unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (AA 261-289) antibodyOTX2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Orthodenticle Homeobox 2 (OTX2) (C-Term) antibodyOTX2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Human fetal gut, colon, liver or heart.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- OTX2 (Orthodenticle Homeobox 2 (OTX2))
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别名
- OTX2
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背景
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CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2 (Drosophila), Orthodenticle homolog 2, Orthodenticle2, Otx 2, otx2,OTX2 / Orthodenticle homeobox 2 (Transcription Factor)
Cellular localisation: Nucleus. -
分子量
- 71.5kDa
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基因ID
- 5015, 288655
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UniProt
- P32243
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途径
- Dopaminergic Neurogenesis
抗原
-
